منابع مشابه
Cyanide toxicity following nitroprusside induced hypotension.
Several recently reported deaths following the use of sodium nitroprusside have been attributed to the accumulation of the nitroprusside metabolite, cyanide. In this study, brief nitroprusside infusions (mean = 36 minutes) were administered in currently recommended doses during intracranial surgery. The peak blood cyanide following the infusions was 65.2 +/- 17.5 microgram per cent (mean +/- SE...
متن کاملThe cerebral response to sodium nitroprusside and trimethaphan controlled hypotension.
THE EFFECTS of altered arterial blood pressure on cerebral blood flow ( CBF ) have been well documented by Lassen 1'2 and Olesen 3 in man, and by Rapela, 4 Waltz ~ and Yashon 6 in dogs. The critical determinants of cerebral blood flow are the cerebral perfusion pressure (CPP) and the cerebrovascular resistance (CVR). The CPP is the difference between the driving force of the mean arterial press...
متن کاملMetabolic effects of induced hypotension with trimetaphan and sodium nitroprusside.
In two groups of patients undergoing induced hypotension with sodium nitroprusside or trimetaphan blood concentrations of lactate, pyruvate and standard bicarbonate did not differ significantly between the groups. In the nine patients who received trimetaphan there was a progressive, but statistically non-significant, decrease in mean lactate. Nitroprusside (15 patients) was associated with a s...
متن کاملEffect of sodium nitroprusside-induced hypotension on pulmonary deadspace.
Deliberate hypotension with nitroprusside produced a 40% reduction in mean arterial pressure, but it did not cause any change in the pulmonary deadspace to tidal volume ratio ( Vb/ Vr). This was achieved by adequate hydration both before and during hypotension, as indicated by constant filling pressures. Thus we have shown that deliberate hypotension per se does not increase Vb/ VT, and that va...
متن کاملCentral and Regional Haemodynamics during Controlled Hypotension Produced by Adenosine, Sodium Nitroprusside and Nitroglycerin
Induced hypotension during anaesthesia was introduced by Gardner in 1946 [1]. Reasons for the use of deliberate hypotension during surgery are to facilitate the surgery and to decrease blood loss [2]. However, in a retrospective series [3] there was an overall incidence of complications of more than 3%, and there is always a risk of underperfusion of vital organs—a hazard that the anaesthetist ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1975
ISSN: 0007-0912
DOI: 10.1093/bja/47.6.739-a